资源类型

期刊论文 30

年份

2023 6

2022 3

2021 6

2020 3

2018 2

2017 3

2016 1

2015 1

2011 1

2010 2

2009 1

展开 ︾

关键词

安全风险 3

死亡 2

人工智能 1

信号检测理论 1

前馈信号 1

叶片受损 1

国家安全 1

大气污染 1

安全系数 1

实时预测 1

对策 1

岩土工程风险 1

岩溶隧道 1

应对策略 1

建筑渣土 1

强人工智能 1

强台风 1

心血管疾病 1

支付风险 1

展开 ︾

检索范围：

排序： 展示方式：

Heterogeneous length-of-stay modeling of post-acute care residents in the nursing home with competing

《工程管理前沿（英文）》   页码 577-591 doi: 10.1007/s42524-022-0203-7

摘要： Post-acute care (PAC) residents in nursing homes (NHs) are recently hospitalized patients with medically complex diagnoses, ranging from severe orthopedic injuries to cardiovascular diseases. A major role of NHs is to maximize restoration of PAC residents during their NH stays with desirable discharge outcomes, such as higher community discharge likelihood and lower re/hospitalization risk. Accurate prediction of the PAC residents’ length-of-stay (LOS) with multiple discharge dispositions (e.g., community discharge and re/hospitalization) will allow NH management groups to stratify NH residents based on their individualized risk in realizing personalized and resident-centered NH care delivery. Due to the highly heterogeneous health conditions of PAC residents and their multiple types of correlated discharge dispositions, developing an accurate prediction model becomes challenging. Existing predictive analytics methods, such as distribution-/regression-based methods and machine learning methods, either fail to incorporate varied individual characteristics comprehensively or ignore multiple discharge dispositions. In this work, a data-driven predictive analytics approach is considered to jointly predict the individualized re/hospitalization risk and community discharge likelihood over time in the presence of varied residents’ characteristics. A sampling algorithm is further developed to generate accurate predictive samples for a heterogeneous population of PAC residents in an NH and facilitate facility-level performance evaluation. A real case study using large-scale NH data is provided to demonstrate the superior prediction performance of the proposed work at individual and facility levels through comprehensive comparison with a large number of existing prediction methods as benchmarks. The developed analytics tools will allow NH management groups to identify the most at-risk residents by providing them with more proactive and focused care to improve resident outcomes.

关键词： nursing home     predictive analytics     individualized prediction     competing risks     health outcomes    

HTML PDF 收藏

Construction risks of Huaying mount tunnel and countermeasures

Haibo YAO, Feng GAO, Shigang YU, Wei DANG

《结构与土木工程前沿（英文）》 2017年 第11卷 第3期   页码 279-285 doi: 10.1007/s11709-017-0414-x

摘要： The Chongqing-Guang’an motorway is planned to cross Huaying mount at Jingguan town of Chongqing city. The whole mount is a colossal anticline whose core is consisted of coal measure strata (upper Permian Longtan formation P l) and the limbs are limestone strata (middle Triassic Leikoupo formation T l and lower Triassic Jialingjiang formation T j). The tunneling is full of risks of collapse, gas explosion or gas outburst, water (mud) inrush, gas inrush because of existence of faults, high pressure gas, karst tectonics and coal goafs around the tunnel. In order to cope with the high risk, two main countermeasures were taken to ensure security of construction. One is geology prediction, and the other is automatic wireless real-time monitoring system, which contains monitoring of video, wind speed, poisonous gas (CH , CO, H S, SO ), people location, and automatic power-off equipment while gas contents being more than warning threshold. These ascertained the engineering safety effectively.

关键词： tunnel?construction     gas?outburst     geology?prediction     automatic?monitoring?system    

HTML PDF 收藏

New medical risks affecting obstetrics after implementation of the two-child policy in China

null

《医学前沿（英文）》 2017年 第11卷 第4期   页码 570-575 doi: 10.1007/s11684-017-0552-5

摘要：

China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted fertility technologies in recent years, the number of elderly women attempting to bear children has increased. The quality of woman’s eggs and a man’s sperm declined dramatically with increasing age, leading to an increased risk of pregnancy-related complications among older women. Therefore, the types of fertility problems experienced by elderly females must be provided with considerable attention by obstetricians. This commentary article focuses on the medical problems faced by older second-child pregnant women. This work discusses their increased rates of infertility, spontaneous abortion, fetal malformation, gestational diabetes, cesarean section, placenta previa, postpartum hemorrhage, postpartum depression, and hypertensive disorders, which complicate pregnancy.

关键词： two-child policy     birth defects     cesarean delivery     placenta previa    

HTML PDF 收藏

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

《医学前沿（英文）》 2011年 第5卷 第4期   页码 356-371 doi: 10.1007/s11684-011-0159-1

摘要： Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the ability to integrate permanently into genomic DNA, thus driving long-term expression of corrective genes in all hematopoietic lineages. To date, HSC gene therapy has been successfully employed in the clinic for improving clinical outcomes in small numbers of patients with X-linked severe combined immunodeficiency (SCID-X1), adenosine deaminase deficiency (ADA-SCID), adrenoleukodystrophy (ALD), thalassemia, chronic granulomatous disease (CGD), and Wiskott-Aldrich syndrome (WAS). However, adverse events were observed during some of these HSC gene therapy clinical trials, linked to insertional activation of proto-oncogenes by integrated proviral vectors leading to clonal expansion and eventual development of leukemia. Numerous studies have been performed to understand the molecular basis of vector-mediated genotoxicity, with the aim of developing safer vectors and lower-risk gene therapy protocols. This review will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem and progenitor cells due to integrating gene transfer vectors, discuss the available assays for predicting genotoxicity and mapping vector integration sites, and introduce newly-developed approaches for minimizing genotoxicity as a way to further move HSC gene therapy forward into broader clinical application.

关键词： gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

HTML PDF 收藏

Occurrence, removal, and environmental risks of pharmaceuticals in wastewater treatment plants in south

Huang Huang, Jie Wu, Jian Ye, Tingjin Ye, Jia Deng, Yongmei Liang, Wei Liu

《环境科学与工程前沿（英文）》 2018年 第12卷 第6期 doi: 10.1007/s11783-018-1053-8

摘要：

Five pharmaceuticals were detected in wastewater treatment plants in southern China.

Biological treatment was the most effective process for PhACs removal.

Metoprolol showed negative removal during secondary treatment process.

The pharmaceuticals studied posed a low environmental risk to aquatic ecosystems.

关键词： Pharmaceuticals     Wastewater treatment     Pearl River Delta     Occurrence     Removal     Risk assessment    

HTML PDF 收藏

Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grown

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1687-z

摘要：

● Organic solvent extracted fewer Cd/Pb in rapeseed oil than physical pressing.

关键词： Rapeseed oil     Oil extraction technologies     Human health risk assessment     Cd/Pb-contaminated farmland     Substitute planting    

HTML PDF 收藏

Composition, dispersion, and health risks of bioaerosols in wastewater treatment plants: A review

Yunping Han, Lin Li, Ying Wang, Jiawei Ma, Pengyu Li, Chao Han, Junxin Liu

《环境科学与工程前沿（英文）》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1330-1

摘要： Abstract • Bioaerosols are produced in the process of wastewater biological treatment. • The concentration of bioaerosol indoor is higher than outdoor. • Bioaerosols contain large amounts of potentially pathogenic biomass and chemicals. • Inhalation is the main route of exposure of bioaerosol. • Both the workers and the surrounding residents will be affected by the bioaerosol. Bioaerosols are defined as airborne particles (0.05–100 mm in size) of biological origin. They are considered potentially harmful to human health as they can contain pathogens such as bacteria, fungi, and viruses. This review summarizes the most recent research on the health risks of bioaerosols emitted from wastewater treatment plants (WWTPs) in order to improve the control of such bioaerosols. The concentration and size distribution of WWTP bioaerosols; their major emission sources, composition, and health risks; and considerations for future research are discussed. The major themes and findings in the literature are as follows: the major emission sources of WWTP bioaerosols include screen rooms, sludge-dewatering rooms, and aeration tanks; the bioaerosol concentrations in screen and sludge-dewatering rooms are higher than those outdoors. WWTP bioaerosols contain a variety of potentially pathogenic bacteria, fungi, antibiotic resistance genes, viruses, endotoxins, and toxic metal(loid)s. These potentially pathogenic substances spread with the bioaerosols, thereby posing health risks to workers and residents in and around the WWTP. Inhalation has been identified as the main exposure route, and children are at a higher risk of this than adults. Future studies should identify emerging contaminants, establish health risk assessments, and develop prevention and control systems.

关键词： Wastewater treatment plant     Bioaerosols     Pathogen     Dispersion     Risk assessment    

HTML PDF 收藏

Legacies and health risks of heavy metals, polybrominated diphenyl ethers, and polychlorinated dibenzo-dioxins

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1679-z

摘要：

● Heavy metals and organic toxins may persist in legacy sites for a long time.

关键词： E-waste     Human health risk     Organ risk     Heavy metal toxicity     PBDE     PCDD/F    

HTML PDF 收藏

Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions

Zhiruo Zhang, Shelan Liu, Mi Xiang, Shijian Li, Dahai Zhao, Chaolin Huang, Saijuan Chen

《医学前沿（英文）》 2020年 第14卷 第2期   页码 229-231 doi: 10.1007/s11684-020-0765-x

摘要： The outbreak of a novel coronavirus disease (COVID-19, caused by the 2019-nCoV infection) in December 2019 is one of the most severe public health emergencies since the founding of People’s Republic of China in 1949. Healthcare personnel (HCP) nationwide are facing heavy workloads and high risk of infection, especially those who care for patients at the epicenter of the outbreak, Hubei Province. Sadly, as of February 20, 2020, over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide, with nearly 90% of them from Hubei Province. Based on literature search and interviews with some HCP working at Wuhan, capital city of Hubei, we have summarized some of the effective measures taken to reduce infection among HCP, and also made suggestions for improving occupational safety during an infectious disease outbreak. The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world.

关键词： healthcare personnel     COVID-19     infectious diseases    

HTML PDF 收藏

Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1682-4

摘要：

● Abundance of MAGs carrying ARG-VF pairs unchanged in rivers after WWTP upgrade.

关键词： Wastewater treatment plant upgrade     Antibiotic resistance genes (ARGs)     Virulence factors (VFs)     Gene co-occurrence     Genome-centric analysis    

HTML PDF 收藏

Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1504-5

摘要：

• Diversity and detection methods of pathogenic microorganisms in sludge.

关键词： Sludge treatment     Pathogenic microorganisms     Inactivation mechanisms     Exposure risks     Land application    

HTML PDF 收藏

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 53-61 doi: 10.1007/s11684-017-0502-2

摘要：

Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.

关键词： acute coronary syndromes     adherence to secondary prevention medications     clinical outcome    

HTML PDF 收藏

海底碳封存环境地质灾害风险及监测技术研究

张少鹏,刘晓磊,程光伟,朱超祁,李清平,何玉发

《中国工程科学》 2023年 第25卷 第3期   页码 122-130 doi: 10.15302/J-SSCAE-2023.03.011

摘要：

海底CO2地质封存是我国实现“双碳”目标的重要组成部分，但CO2泄露具有诱发海底地质灾害的风险，威胁海洋工程的安全建设，因此开展封存区环境地质监测对海洋碳封存实施具有重要的现实意义。本文在简要介绍海底CO2地质封存示范案例的基础上，阐述了海底封存区CO2泄露的致灾机制，结合实例梳理了典型CO2控释试验中的海洋环境监测技术，重点分析了与CO2泄露相关的环境地质监测技术，包括地震调查与监测、电阻率法监测技术、重力监测技术、海床变形监测技术以及沉积物孔隙压力监测技术等，展望了我国海底碳封存及其环境地质监测的未来发展前景。研究认为，今后应侧重封存区CO2泄露致灾机制与环境地质监测技术研究，建议在研发长时序、低成本并实时监测技术的基础上，结合封存区基线调查，建立和发展系统性、智能性的多维度灾害识别模型，构建多方面、多层次、多灾种的监测预警预报体系。

关键词： 海底碳封存；环境地质；CO2泄露；灾害风险；监测技术    

HTML PDF 收藏

宜万铁路岩溶隧道风险管理

朱鹏飞

《中国工程科学》 2009年 第11卷 第12期   页码 20-25

摘要：

宜万铁路地形、地质条件之复杂，集西南山区铁路之大成。建设条件之艰、难、险居我国铁路历史之最。为减少岩溶突水突石的灾害发生，首次引入了风险管理的理论并应用到实践之中，第一次提出了高风险的概念，建立了系统全面的应对高风险管理措施，其中地质勘察监理、超前地质预报、安全分级管理、水文监测、防灾报警系统等应对措施是第一次在铁路工程中进行了研究和应用。为其他岩溶隧道的风险管理提供了思路和方法。

关键词： 岩溶隧道     风险管理     风险应对措施    

HTML PDF 收藏

全球气候变化风险不断加剧的背景下，中国的可持续性管理和行动

丁一汇

《工程（英文）》 2018年 第4卷 第3期   页码 301-305 doi: 10.1016/j.eng.2017.12.014

HTML PDF 收藏

标题 作者 时间 类型 操作

Heterogeneous length-of-stay modeling of post-acute care residents in the nursing home with competing

期刊论文

Construction risks of Huaying mount tunnel and countermeasures

Haibo YAO, Feng GAO, Shigang YU, Wei DANG

期刊论文

New medical risks affecting obstetrics after implementation of the two-child policy in China

null

期刊论文

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

期刊论文

Occurrence, removal, and environmental risks of pharmaceuticals in wastewater treatment plants in south

Huang Huang, Jie Wu, Jian Ye, Tingjin Ye, Jia Deng, Yongmei Liang, Wei Liu

期刊论文

Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grown

期刊论文

Composition, dispersion, and health risks of bioaerosols in wastewater treatment plants: A review

Yunping Han, Lin Li, Ying Wang, Jiawei Ma, Pengyu Li, Chao Han, Junxin Liu

期刊论文

Legacies and health risks of heavy metals, polybrominated diphenyl ethers, and polychlorinated dibenzo-dioxins

期刊论文

Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions

Zhiruo Zhang, Shelan Liu, Mi Xiang, Shijian Li, Dahai Zhao, Chaolin Huang, Saijuan Chen

期刊论文

Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence

期刊论文

Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review

期刊论文

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

null

期刊论文

海底碳封存环境地质灾害风险及监测技术研究

张少鹏,刘晓磊,程光伟,朱超祁,李清平,何玉发

期刊论文

宜万铁路岩溶隧道风险管理

朱鹏飞

期刊论文

全球气候变化风险不断加剧的背景下，中国的可持续性管理和行动

丁一汇

期刊论文